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Biochemistry

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Decoding the Building Blocks

The average person has about 36 billion cells and organisms in their body.

Contained within a tiny fraction of this organic material are the DNA, the blueprints and instructions needed to keep the body regulated, from cell division and organ health, to immune system upkeep and respiration.

Our bodies are walking, talking, functioning reminders that relative size has no bearing on importance or relevance, and that some of the most powerful forces in the universe exist at the smallest level.

All life on Earth depends on biochemical reactions and processes such as these, whether it’s the building of complex proteins in your cells or the conversion of energy by photosynthesis in plants. Life is a cycle and network of biochemical activity.

The Northeastern biochemistry program incorporates the fields of physics, biology, chemistry, and mathematics to provide a holistic understanding of the mechanisms of life at every scale.

Coursework and Requirements
A sampling of the types of courses you could take here.
Cell and Molecular Biology
BIOL 4707

Integrates molecular biology and biochemistry in the cellular context. Focuses on the organization and function of eukaryotic cells, including the regulation of nuclear structure and gene expression, signal transduction, protein synthesis and growth, cellular energetics, the cytoskeleton and cell motility, cell division, and cell death. Emphasizes the scientific methodologies and approaches that underlie discovery in cell biology.

Genetics and Molecular Biology
BIOL 2301

Focuses on mechanisms of inheritance, gene-genome structure and function, and developmental genetics and evolution. Examples are drawn from the broad spectrum of plants, animals, fungi, bacteria, and viruses. Topics and analytical approaches include transmission genetics, molecular biology and gene regulation, DNA molecular methods, quantitative and population genetics, bioinformatics, genomics, and proteomics.

Introduction to Protein Chemistry
CHEM 4620

Introduces protein chemistry in the context of molecular medicine. Discusses analytical methods used to elucidate the origin, structure, function, and purification of proteins. Surveys the synthesis and chemical properties of structurally and functionally diverse proteins, including globular, membrane, and fibrous proteins. Discusses the role of intra- and intermolecular interactions in determining protein conformation, protein folding, and in their enzymatic activity.

Magnify your Learning with Co-op

Starting around sophomore year, Northeastern’s unique co-operative education program allows biochemistry students to explore different pathways and potential careers both locally and around the globe. Hear what previous biochemistry students had to say about their experience with the program:

Brian Cortese, Biochemistry’19

“There’s a lot more to it than just learning the bench and the skills, it’s about how to think, it’s about meeting new people, and it’s really all about the mentorship that will help you reach your potential long term.”

Zoe Bishop, Biochemistry Major

“My first co-op PI was on the admissions board for Harvard Medical School– talk about friends in high places! He’s helped me make important decisions, and I’m very thankful for that level of mentorship.”

Kalil Menezes, Biochemistry Major

Co-op took me to Belgium where I spent weekdays in the neuroscience lab and weekends making unforgettable memories with friends.

Brian

Faculty Research

Biochemistry
Cram Lab
The Cram Laboratory utilizes the model organism Caenorhabditis elegans as an in vivo system to examine how mechanical forces are sensed and interpreted by cells and how this influences cell migration. In  addition, they collaborate with Chemical Engineers to improve production of drug compound..
Biochemistry
Ebong Lab
The Ebong Lab studies the means by which endothelial cell mechanotransduction occurs in order to prevent or promote atherosclerosis
Biochemistry
Godoy Lab
The Godoy lab seeks to learn about the mechanism(s) regulating the activity of potentially mutagenic DNA polymerases.
Biochemistry
Shefelbine Lab
The Shefelbine Lab studies multiscale mechanics and musculoskeletal mechanobiology.
Biochemistry
Slavov Laboratory
The Slavov Lab studies Ribosome-mediated translational regulation, and single-cell proteomics by mass-spectrometry
Biochemistry
Theoretical Soft Matter and Biophysics Group
This reearch group is interested in understanding collective and emergent behavior in out-of-equilibrium and disordered systems. The research employs methods in theoretical and computation condensed matter physics and applies to a wide range of biological and non-biological systems.
Biochemistry
Biomedical Optics Research Group
This group studies biomedical optics and non-invasive imaging, rare cell detection and tracking in the body, ultrafast time-domain diffuse optical imaging, image reconstruction and biomedical signal processing.
Biochemistry
Respiratory Innovation and Simulation Team
This lab combines state-of-the-art experimental and numerical methods to quantify the health impacts of inhaled toxins (e.g. e-cigs) or to optimize inhaled therapeutics.
Biochemistry
Ondrechen Research Group
Prof. Ondrechen’s research group spans the areas of theoretical and computational chemistry, computational biology, bioinformatics, protein design, and drug discovery. Areas of interest include functional genomics – predicting the biochemical functional roles of gene products (proteins), protei..
Biochemistry
Sage Lab
Professor Sage’s research is motivated by a fascination with the physical basis for the function of proteins. He develops and applies novel spectroscopic approaches to understand the structure, dynamics, and function of biological macromolecules.
Biochemistry
Spring Lab
Professor Spring’s group bridges biophysics, biomedical optics and cancer biology to selectively target micrometastases left behind by standard therapies that limit our ability to cure many cancers.
Biochemistry
Neurogeometry Lab
Research in this lab is aimed at understanding the basic brain functions and principles of synaptic connectivity in the cerebral cortex through the quantitative analysis of neuron morphology.
Biochemistry
Venkatachalam Lab
Studies of the neurophysiology of C. elegans from its birth to adulthood, which reveals the detailed relationship between the developing nervous system and the animal behavior. Advanced neurotechnology and microscopy techniques are used to measure large populations of neurons in freely beh..
Biochemistry
Whitford Research Group
Professor Whitford’s research probes the energetic properties of biomolecular dynamics through a combination of theoretical modeling and high-performance computing (HPC). His investigations of biomolecular order-disorder transitions and energy transduction processes span from protein and ribo..
Biochemistry
Cell & tissue Engineering Lab (CEL)
The Asthagiri lab investigates how cancer cells acquire the ability to invade their surroundings, a key early step in the lethal progression to metastasis. They seek to identify robust therapeutic strategies to target cancer cells whose heterogeneity and plasticity make them a "moving target."
Biochemistry
Auguste Lab
The Auguste lab engineers solutions to address current challenges in medicine. They design, synthesize, and evaluate new biomaterials that change the way we deliver drugs and cells.
Biochemistry
Molecular Bioelectrostatics & Drug Delivery Laboratory
The Bajpayee lab works on drug delivery to connective and charged tissues such as cartilage, meniscus, intervertebral disc and mucosal membranes.
Biochemistry
Laboratory for Advanced and Multifunctional Polymeric Biomaterials
The overall focus of the research in the Bencherif LAMP Biomaterials Laboratory is the fundamental understanding and development of polymeric materials for biomedical applications with a specific emphasis on tissue engineering, drug delivery, and cancer immunotherapy.
Biochemistry
Advanced Drug Delivery Research Lab
The ADDRES Lab studies interactions between materials and biological systems, with a current focus on the intestinal environment, via development of theoretical and tissue-engineered cell culture models. 
Biochemistry
Goluch Group
The primary focus of this research is the development of detection strategies that are tailored for the micro and nanoscale, with emphasis on biological systems.
Biochemistry
Laboratory for Neuromodulation and Neuromuscular Repair
This research focuses on the intersectionality between biomaterials, electronics, nerves, and the heart.
Biochemistry
Lee-Parsons Research Laboratory Website
This research group is applying metabolic engineering principles and methodologies to improve the production of important compounds, i.e. critical plant-derived pharmaceuticals or biofuels, from plant cell & tissue cultures and microalgae cultures.
Biochemistry
Detrich Lab
One central strategy of the Detrich Lab's work is the comparative approach to adaptational evolutionary biology – they use phylogenetically controlled contrasts to evaluate molecular causation in natural experiments, such as the evolution of proteins to function efficiently at cold temperatur..
Biochemistry
Lotterhos Lab
The Lotterhos Lab at Northeastern Marine Science Center seeks to understand how climate has shaped marine biodiversity and how a now rapidly changing climate will affect biodiversity in the future.
Biochemistry
Vollmer Lab
This research group studies the evolution and ecology of marine organisms using cutting-edge, next-generation sequencing, which had revolutionized molecular genetics by providing unprecedented access to the genetic variation in any organism’s genome or transcriptome.
Biochemistry
Amiji Group
The  research effort in the Laboratory of Biomaterials and Advanced Nano-Delivery Systems (BANDS) is focused on the development of biocompatible materials from natural and synthetic polymers, target-specific drug and gene delivery systems for cancer, CNS, inflammatory, and infectious diseases, and..
Biochemistry
Epstein Lab
The Epstein lab works on microbial discovery in the environment and human microbiome. They uncover novel microbial life forms by inventing novel cultivation strategies that depart from conventional wisdom and provide access to the greatest part of microbial diversity: unexplored species missed ..
Biochemistry
Lewis Lab
The Lewis Lab studies persister cells responsible for tolerance to antibiotics, uncultured bacteria of the environment and the microbiome, and works on drug discovery.
Biochemistry
O'Doherty Group
This research group has been working in two related areas of organic synthesis: carbohydrate synthesis and natural product synthesis.  The unifying theme that connects the research in these two areas is the method of synthesis (asymmetric catalysis) and target selection (anti-cancer, anti-viral an..
Biochemistry
Laboratory for Neglected Disease Drug Discovery
This research program focuses on those areas of research that will impact on treatment of human disease and on areas that will expedite the drug discovery process.
Biochemistry
Beuning Lab
The Beuning laboratory at Northeastern is focused on understanding the structure-function-dynamics relationships of proteins and enzymes, with a particular focus on proteins involved in DNA metabolism and DNA damage tolerance.
Biochemistry
Biomaterials Design Group
The Biomaterials Design Group at Northeastern University works at the interface of bio-analytical chemistry, materials science, and design. We investigate fundamental mechanisms behind systems in biology and use our understanding to better inform the design new classes of protein-based biomaterials..
Biochemistry
Engen Lab
The Engen Lab uses hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.
Biochemistry
Thakur Lab
The Thakur Lab's research has a multi-dimensional aspect with a focus on treating a plethora of diseases and disorders. They target receptors like cannabinoid, nicotinic, and other protein complexes with the intent of designing pharmacotherapy for Alzheimer's disease, schizophrenia, anorexia ne..
Biochemistry
Wanunu Lab
Professor Wanunu’s research involves studying biosystems at the nanoscale (macromolecular and sub-molecular levels).
Biochemistry
Williams Lab
The Williams lab specializes in the development of single molecule methods for quantitatively probing the biophysical properties of DNA and RNA and for understanding the biophysics of their interactions with proteins and other DNA binding ligands.
Biochemistry
Zhang Group
The Zhang group develops macromolecular systems to provide answers to important questions in biology and medicine.
Biochemistry
SunnyLand
SunnyLand applies protein chemistry, analysis and engineering to biology and medicine.
Biochemistry
Apfeld Lab
The Apfeld Lab seeks to dissect the interplay between redox processes and age-dependent changes in tissue function in the nematode C. elegans, in order to shed light on the association between the dysregulation of the cellular redox environment and many human diseases of aging.
Biochemistry
NeuroLab
NeuroLab focuse on a new invertebrate model for central nervous system regeneration and the development of advanced devices for microscopy and imaging.
Biochemistry
Crane Lab
The Crane Lab investigates why cells deteriorate with aging and other diseases with a focus on cell metabolism. 
Biochemistry
Advanced Biomaterials for Neuroengineering Laboratory
The focus of the Advanced Biomaterials for Neuroengineering Laboratory (ABNEL) is developing novel and transformative devices, biomaterials, and biophysical-based therapies for neuropathies in the Central, Peripheral, and Enteric nervous systems.
Biochemistry
Woods Laboratory
The Woods Laboratory is interested in studying the role of mitochondria in normal and disease states, with a major emphasis on female reproductive function and health. 
Biochemistry
Laboratory of Neurobiology
Research in Prof. Zupanc’s laboratory focuses on the exploration of neural mechanisms underlying structural plasticity in the adult central nervous system of vertebrates. 
Biochemistry
Larese-Casanova Research Group
Our current projects are studying the biogeochemical cycling of selenium, the fate of metallic particles in aquatic environments, and ways to improve drinking water treatment using synthesized carbonaceous materials.
Biochemistry
Champion Lab
The Champion lab studies the structure and dynamics of biomolecules using a variety of ultrafast laser-based techniques.
Biochemistry
Research Alliance in Science and Engineering (RAISE)
Through integrative education and collaboration between undergraduate chemistry students and faculty mentors, RAISE continues the teaching curriculum beyond the classroom and into the real world.
Biochemistry
Budil Lab
Prof. Budil’s group is interested in the physical behavior of macromolecules, including both synthetic polymers and biopolymers such as large proteins. Their principal investigative tool is electron spin resonance (ESR) spectroscopy, including very high-frequency ESR.
Biochemistry
Ban-An Khaw Lab
The aim of Ban-An Khaw's research is to develop new approaches for diagnosis of various cardiovascular diseases and cancer, and to use them to further the understanding of the pathogenesis of these disorders to formulate novel therapies.
Biochemistry
Makowski Lab
Image and signal processing as applied to biophysical data designed to answer fundamental questions about the molecular basis of living systems
Biochemistry
Bellini Lab
Chiara Bellini studies diseases of the cardiovascular system and the effects of cellmediated growth and remodeling processes on tissue and organ mechanics.
Biochemistry
Dai Lab
Guohao Dai's research focuses on 3-D bioprinting technology, stem cells technology, and vascular bioengineering.
Biochemistry
Murthy Lab
Shashi Murthy's research focuses on microfluidic isolation of stem and progenitor cells, point-of-care diagnostics, cell surface phenomena during microfluidic flow, nanoscale probes for cell stimulation, and biopassive/bioactive coatings for neurological implants.
Biochemistry
Parameswaran Lab
Harikrishnan Parameswaran's research focuses on cell-extracellular matrix interactions, force transmission in multicellular ensembles, asthma, pulmonary physiology.
Biochemistry
Ruberti Lab
Jeffrey Ruberti's research focuses on tissue engineering of load-bearing matrix (bone, cornea), bioreactor design, multi-scale mechanobiochemistry, statistical mechanics, energetics microscopy, high-resolution imaging, and biopolymer self-assembly.
Biochemistry
Stubbins Lab
Aron Stubbin's research fouses on environmental chemistry, geochemistry, the carbon cycle, freshwater, coastal and ocean biogeochemistry, feedbacks between natural biogeochemical cycles and climate change, permafrost, black carbon, and aquatic microplastics
Biochemistry
Yunrong Chai's Lab
Yunrong Chai's lab is interested in understanding fundamental mechanisms controlling bacterial biofilm formation and the role of beneficial biofilms in bacteria-host interactions. They are also interested in inhibitory mechanisms targeting key processes during bacterial biofilm development.
Biochemistry
Geisinger Lab
The Geisinger lab investigates the molecular basis of antibiotic resistance and disease development in infections with hospital-acquired pathogens.
Biochemistry
Hanson Research Group
Professor Hanson’s research group focuses on the application of synthetic organic chemistry to the development of new diagnostic and therapeutic agents for neoplastic diseases.
Biochemistry
Oyinda Oyelaran's Lab
Oyinda Oyelaran is the co-PI of the Chemistry and Chemical Biology department's NSF-REU site program.
Biochemistry
Torchilin lab
Vladimir Torchilin's lab is conducting research on long-circulating and targeted pharmaceutical carriers for drugs and diagnostics in a variety of in vitro and in vivo models.
Biochemistry
Day Lab
The Day Lab investigates the molecular role of G quadruplex DNA in genome stability and human diseas
Biochemistry
Logothetis Lab
Diomedes Logothetis's research brings together Medicinal Chemistry, Drug Delivery, Pharmacology/Physiology, and Structural Biology with the aim to form a solid foundation of pre-clinical studies on the action of pharmaceuticals and naturally occurring substances.
Biochemistry
Mattos Lab
Research in the Mattos Lab focuses on understanding the rules that govern the recognition, assembly and function of macromolecular complexes.
Biochemistry
Miller Lab
Greg Miller's lab focuses on the neurobiology, immunology and genetics associated with acute and chronic exposure to drugs of abuse. Their goals are to understand how drugs of abuse work in the brain and the body, to create new pharmacological treatment strategies for people who are addicted and mo..
Biochemistry
Khrapko's Lab
Khrapko's lab is studying mutations in mtDNA and their effects on cellular physiology, aging and disease. THey also use mtDNA mutations to trace mtDNA lineages and to study human evolution.
Biochemistry
Tilly's Lab
Tilly's lab seeks to promote a deeper understanding of the genetic and epigenetic drivers of cell lineage specification, differentiation and death, and to then utilize the information gained from these studies for development of innovative new technologies to improve human health within and across ..
Biochemistry
Booth Lab
The Booth lab undertakes drug developing starting with a GPCR structure-based ligand design approach using molecular modeling experiments, followed by synthesis of target ligands and in vitro molecular pharmacology assays to delineate their a nity and function.
Biochemistry
Chemical Imaging of Living Systems Institute
The Institute develops imaging tools to highlight chemical processes - enabling clinicians to better diagnose and treat disease.
Biochemistry
Center for Complex Network Research (CCNR)
The Center’s objective is simple: think networks. Research focuses on how networks emerge/evolve, how they look, and how they impact our understanding of complex systems. CCNR’s research has developed to unexpected areas, including the topology of the World Wide Web; complex networks inside th..
Biochemistry
New England Inflammation and Tissue Protection Institute
This institute focuses on the role of tissue inflammation in fighting disease and infection, and the mechanisms that control tissue inflammation in the body. The Institute’s work has immediate implications for anti-cancer strategies and approaches to improved vaccines.
The Minds Behind COS Biochemistry
Faculty Spotlight
Leila Deravi
Chemistry
The Biomaterials Design Group at Northeastern University works at the interface of bio-analytical chemistry, materials science, and design. They investigate fundamental mechanisms behind systems in biology and use our understanding to better inform the design new classes of protein-based biomaterials that may interface with or enhance the performance of humans.
John Engen
Chemistry
Current research projects in the Engen laboratory include (1) investigations of kinase conformation to understand regulation and aberrant signaling in various disease states including cancer, (2) analysis of the conformation of viral accessory proteins from HIV, (3) studies of protein conformation at biological membranes, and (4) optimization and methods development in hydrogen exchange mass spectrometry.
Penny Beuning
Chemistry
One type of research in the Beuning lab aims to determine how cells respond to DNA damage and maintain the accuracy of genetic information interactions between DNA replication and DNA damage tolerance. As part of this work, the lab aims to develop DNA damage tolerance enzymes and DNA repair proteins as tools for biotechnology applications.
James Monaghan
Biology
Professor Monaghan’s lab uses the axolotl salamander to investigate the cellular and molecular basis of complex tissue regeneration. Axolotls have the amazing ability to regenerate large portions of their limbs, tail, heart, and spinal cord. His lab studies the development and regeneration of the nervous system and limb and the interactions that take place between these organ systems.
Kim Lewis
Biology
The Lewis Lab studies persister cells and uncultured bacteria. Persisters are dormant variants of regular cells which are tolerant to antibiotics and responsible for recalcitrance of biofilm infections. Using transcriptome analysis, cell sorting and whole genome sequencing the lab faculty are identifying genes responsible for persister formation.
Kirsten Fertuck
Biochemistry
At Northeastern Fertuck teaches Biochemistry, as well as freshman-level Inquiries in Cell and Molecular Biology. She's also also taught advanced-level Molecular Cell Biology. She focuses on the effects of pollutants on signaling through the estrogen receptor.

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