About Gunther Zupanc
Research in Prof. Zupanc’s laboratory focuses on the exploration of neural mechanisms underlying structural plasticity in the adult central nervous system of vertebrates. In particular, he is interested in the generation of new neurons in the adult brain and spinal cord (‘adult neurogenesis’) and in the replacement of neurons damaged through injury by newly generated ones (‘neuronal regeneration’).
His investigations are carried out in teleost fish, as these vertebrates – very much in contrast to mammals – exhibit an enormous potential to generate new neurons in both the intact and the injured central nervous system during adulthood. By combining cellular, neuroanatomical, neurophysiological, and behavioral approaches, he and his group attempt to identify key mechanisms underlying this production of new neurons, and to learn more about the behavioral consequences of the resulting structural dynamics of neural networks.
The ultimate goal of Prof. Zupanc’s research is to understand the evolutionary factors that have led to the enormous reduction of the neurogenic potential in mammals, while maintaining the generation of new neurons at high levels in the central nervous system of many non-mammalian taxa. Such a comparative approach will not only be essential to gain a biological understanding of adult neurogenesis, but also bears an enormous potential to open new vistas for the development of novel therapeutic strategies to replace neurons lost to injury or degenerative disease by newly generated ones.
Research in Prof. Zupanc’s laboratory focuses on the exploration of neural mechanisms underlying structural plasticity in the adult central nervous system of vertebrates.
- Ilieş, I., Sipahi, R., Zupanc, G.K.H.: Growth of adult spinal cord in knifefish: development and parametrization of a distributed model.Read
- Sîrbulescu, R.F., Ilieş, I., Meyer, A., Zupanc, G.K.H.: Additive neurogenesis supported by multiple stem cell populations mediates adult spinal cord development: a spatiotemporal statistical mapping analysis in a teleost model of indeterminate growth.Read
- Zupanc, G.K.H.: Mapping brain structure and function: cellular resolution, global perspective.Read
- Zupanc, G.K.H., Stocum, D.L.: Regeneration science needs to broaden its focus to understand why some organisms can regenerate – and others not.Read
- Salisbury. J.P., Sîrbulescu. R.F., Moran, B., Auclair. J.R., Zupanc, G.K.H., Agar, J.N.: The central nervous system transcriptome of the weakly electric brown ghost knifefish (A. leptorhynchus): de novo assembly, annotation, and proteomics validationRead