About John Engen
Current research projects in his laboratory include (1) investigations of kinase conformation to understand regulation and aberrant signaling in various disease states including cancer, (2) analysis of the conformation of viral accessory proteins from HIV, (3) studies of protein conformation at biological membranes, and (4) optimization and methods development in hydrogen exchange mass spectrometry.
Institutes, Labs & Research Centers
Engen Lab
Chemistry and Chemical Biology
Biochemistry
The Engen Lab uses hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.
Faculty
Publications:
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John Engen in the news
April 28, 2021
He studies how proteins change in reaction to drugs
John Engen is the James L. Waters chair in analytical chemistry and distinguished professor of chemistry and chemical biology in the College of Science. Photo by Ruby Wallau/Northeastern University
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December 14, 2020
Dry Ice Can Do More than Make Fog. It’s Key to Keeping the COVID-19 Vaccine Cold.
Exploring how dry ice is helping move vaccines and save lives
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April 22, 2019
‘What Happens on the Molecular Level to Make Us Sick?’
Isaac Kresse, a chemistry and computer engineering student at Northeastern, has been awarded a Fulbright Scholarship, which he will use to study the role of chaperone proteins in age-related diseases such as Huntington’s, Alzheimer’s, and Parkinson’s.
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January 31, 2018
Chemistry professor working to help people with fatal genetic disorder
Professor John R. Engen and Professor Timothy Springer of Harvard Medical School publish paper about the molecular basis of Myostatin activation.
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May 15, 2012
Collaborating to Fight Cancer with Knowledge
Researchers at Northeastern University and the Dana-Farber Cancer Institute have long recognized and taken advantage of the complementary strengths of the two institutions. “Our collaboration with Dana-Farber has been rich over the years,” said Stephen Zoloth, Northeastern’s dean of academic affairs for external programs and vice provost for health research. “But it has generally been […]
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