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Behavioral Neuroscience

Training Students to Transform Cancer Treatment
It’s Time To Correct Neuroscience Myths
Male Animals Hold a Monopoly on Research. That’s a Problem.

Journey to the Start

Einstein once wrote that “The world we have created is a product of our thinking; it cannot be changed without changing our thinking.” Discoveries, innovation, languages, social progress, even entire societies were built on humankind’s actions, as driven by its thoughts.

Yet at its base level, an idea is nothing more than an electro-chemical reaction, with neurons delivering rapid-fire messages across the synapses in our brains. To understand how thought becomes action, we must start where thought begins — within the brain structures and mechanisms themselves.

It is within these physical transmissions that a beautiful and complex mix of communication is taking place. Interpretations, reasoning, and learning are happening here, all at once. And somehow, this cacophony of lightspeed movement harmonizes together to form the endpoint that drives actions and behaviors themselves. 

The Behavioral Neuroscience program, one of the most established programs in the United States, seeks to trace the connections and uncover the nature of how these mysterious transmissions transform from thoughts into actions.

Degree Options

Coursework and Requirements
A sampling of the types of courses you could take here.
Neural Systems and Behavior
BIOL 3601

Reviews major experimental approaches and key concepts used in behavioral neurobiology. Topics covered include spatial orientation and sensory guidance, neuronal control of motor output, neuronal processing of sensory information, sensorimotor integration, neuromodulation, circadian rhythms and biological clocks, behavioral physiology of large-scale navigation, neurobiology of communication, and cellular mechanisms of learning and memory.

Neuropsychology of Fear
PSYC 3506

Explores our understanding of the physiological and cognitive aspects of fear, from early theories of emotion to current research in both humans and animal models. Emphasizes linking brain structure to function—how do different brain regions contribute to fear processing and expression? Also focuses on psychiatric illnesses whose symptoms suggest a maladaptive fear response, such as post-traumatic stress disorder and phobias.

Sensation and Perception
PSYC 3452

Discusses how our five senses work to aid us in perceiving states of the body and of the world, how our perceptions are modified by what we know and expect, and how sensation and perception develop (especially in infancy). Includes discussion of neural and anatomical bases of sensation and perception.

PreMed & PreHealth

Our PreMed and PreHealth Advising program offers personalized expertise to COS students pursuing careers in health careers. This comprehensive program includes application guidance, workshops and presentations, course mapping and more.

Learn More

Co-Op

Students studying behavioral neuroscience have the option to pursue many different career paths. Northeastern’s Cooperative Education (co-op) program allows students the ability to explore these types of career options by gaining practical experience working in the field with local, domestic and international employer partners.

CHECK OUT WHERE OUR CO-OPS HAVE WORKED

Faculty Research

Behavioral Neuroscience
Developmental Neuropsychobiology Laboratory
Dr. Brenhouse’s lab studies the dynamic interaction between the brain, the body, and the environment throughout early life and adolescent development. Using animal models with genetic, behavioral, and pharmacological manipulation, her laboratory investigates why later manifestation of mental illn..
Behavioral Neuroscience
The CTNI
Work at the CTNI is focused on four major areas 1) Alzheimer’s disease, 2) Parkinson’s disease 3) repetitive mild traumatic brain injury, and 4) opioid addiction. Preclinical animal models for each of these problems in human health are studied using non-invasive magnetic resonance imaging to fo..
Behavioral Neuroscience
Neurotransmission and Brain Plasticity Lab
The Neurotransmission and Brain Plasticity Lab studies how exposure to cocaine (and other psychostimulants including methamphetamine) during pregnancy affects neuronal interactions in the fetus throughout development.
Behavioral Neuroscience
Laboratory of Neuroanatomy and Behavior
Stress-related mental illnesses like Post-Traumatic Stress Disorder (PTSD) and Major Depressive Disorder (MDD) are twice as common in women, but relevant pre-clinical research on the mechanisms of stress and fear has primarily been conducted in male animals. Our work explores the relationships ..
Behavioral Neuroscience
Action Lab
Motor skills such as throwing a ball, eating with knife and fork or dancing are uniquely human and key to functional behavior. Optimizing the acquisition and preventing or reverting the degradation of skill requires a rigorous quantitative understanding. The Action Lab analyzes how human neurop..
Behavioral Neuroscience
Language and Mind Lab
The Language & Mind Lab studies how the mind works and how we (laypeople) think it does, concentrating on the concept of innate knowledge.
Behavioral Neuroscience
Miller Lab
Greg Miller's lab focuses on the neurobiology, immunology and genetics associated with acute and chronic exposure to drugs of abuse. Their goals are to understand how drugs of abuse work in the brain and the body, to create new pharmacological treatment strategies for people who are addicted and mo..
Behavioral Neuroscience
O'Malley Lab
Dr. O’Malley studies the computational capabilities of neuronal populations at the core of nervous systems, including everything from sensorimotor transformations to more complex behaviors. Current projects are aimed at understanding symbolic operations in mammalian cortex.
Behavioral Neuroscience
Dr. Rosengaus’ Lab
Dr. Rosengaus’ research tries to understand the factors that may have selected for the evolution of insect sociality. This work is at the interface of evolutionary biology, behavioral and chemical ecology, immunology and genetics. Social insects represent excellent social test organisms to answer..
Behavioral Neuroscience
Neurogeometry Lab
Research in this lab is aimed at understanding the basic brain functions and principles of synaptic connectivity in the cerebral cortex through the quantitative analysis of neuron morphology.
Behavioral Neuroscience
Aggression Lab
Dr. Melloni studies the neurobiology of aggressive behavior. The main goal of this research is to understand how drug use and exposure to social stress during adolescence alter brain development and influence aggressive behavior.
Behavioral Neuroscience
Center for Neurophysiology
Dr. Sikes specializes in the neurophysiology of the cingulate cortex; in particular, the role of cingulate cortex in pain sensation.  Research has included pathway investigation to understand pain information transmission, and now focuses on contrasting the effects of somatic and visceral noxio..
Behavioral Neuroscience
Laboratory of Neurobiology
Research in Prof. Zupanc’s laboratory focuses on the exploration of neural mechanisms underlying structural plasticity in the adult central nervous system of vertebrates. 
Behavioral Neuroscience
Biomimetic Underwater Robot Program
Dr. Ayers' research focus is on the neuroethology of motor systems in invertebrates and lower vertebrates and the application of this knowledge to the development of advanced robots.
Behavioral Neuroscience
Denise Jackson's Lab
The primary focus of Dr. Jackson’s research is on how exposure to cocaine (and other psychostimulants including methamphetamine) during pregnancy affects neuronal interactions in the fetus throughout development. We utilize neurochemical and behavioral strategies to assess alterations in brain ar..
Behavioral Neuroscience
Monaghan Lab
Dr. Monaghan’s lab uses the axolotl salamander to investigate the cellular and molecular basis of complex tissue regeneration. Axolotls have the amazing ability to regenerate large portions of their limbs, tail, heart, and spinal cord. His lab studies the development and regeneration of the nervo..
The Minds Behind COS Behavioral Neuroscience
Faculty Spotlight
Rebecca Shansky
Behavioral Neuroscience
Shansky’s research focuses on the neural connections between the medial prefrontal cortex and the amygdala, and sex differences in how this circuit processes fear and responds to stress.
Dagmar Sternad
Behavioral Neuroscience
Sternand’s Action Lab research studies the neural activity of human subjects during movement. These work has been the basis of studies for neurological disorders such as Parkinson’s disease, stroke patients, and children with motor disorders.
Günther Zupanc
Behavioral Neuroscience
Zupanc’s research focuses on neural plasticity in the adult central nervous system of teleost fish, and on the role of structural changes of neurons in behavioral plasticity.
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Childhood Trauma Changes Your Brain. But It Doesn’t Have to Be Permanent.

In the early 1990s, more than 100,000 children in Romania were living in overcrowded, under-funded orphanages. They suffered from severe neglect, having little interaction with caretakers.

This lack of nurturing altered the structure and function of their brains. These children developed a host of behavioral and emotional problems that many of them are still coping with today.

Now, neuroscientists at Northeastern are using rats to understand some of the physical changes in the brain caused by such severe neglect.

In a recent paper, the researchers found that female rats, in particular, developed abnormal connections between two areas of the brain in response to neglect. These are the same areas that show abnormal activity in brain scans of children raised in orphanages, as well as those who have suffered from child abuse or other forms of severe maltreatment. Children with this abnormal activity are more likely to develop anxiety later on in childhood or adolescence.

[Top Right] Heather Brenhouse, associate professor of psychology, right, watches as doctoral student Kelsea Gildawie cleans slices of rat brains. [Bottom Right] Doctoral student Lauren Granata studies a rat brain in Heather Brenhouse’s lab. Photos by Ruby Wallau/Northeastern University

[Top Right] Heather Brenhouse, associate professor of psychology, right, watches as doctoral student Kelsea Gildawie cleans slices of rat brains.[Bottom Right] Doctoral student Lauren Granata studies a rat brain in Heather Brenhouse’s lab. Photos by Ruby Wallau/Northeastern University

“The early work looking at biological underpinnings of this specific circuitry has been largely in male animals,” says Jennifer Honeycutt, a postdoctoral researcher at Northeastern and the lead author on the paper. “We were able to not only expand what we know about generally how the circuitry is developing in both sexes, but now we can pinpoint a possible locus of unique vulnerability for females.”

Honeycutt and her colleagues were examining the connections between the basolateral amygdala, part of an almond-shaped structure tucked in near your temple, and the prefrontal cortex, which is right behind your forehead.

When you see something that might be a threat (say, a tiger), your amygdala fires off signals to several areas of the brain, including the prefrontal cortex, indicating that you should be frightened. The prefrontal cortex responds by integrating information from other areas of the brain, like context clues (The tiger can’t reach us.) or prior memories (This is a zoo. We’ve been to a zoo before), and signals the amygdala to, essentially, calm down.

“The disruption of this circuit is going to lead to maladaptive behaviors,” Honeycutt says. “That’s where you start to see increasing anxiety-like behaviors even in the absence of something that could be anxiety-provoking.”

The connections between the amygdala and the prefrontal cortex develop throughout childhood and adolescence. Research has demonstrated, however, that these connections seemed to develop abnormally in children who had experienced severe neglect and later developed anxiety-like disorders.

“This circuit was showing accelerated maturation,” says Heather Brenhouse, an associate professor of psychology at Northeastern. “It was as if the brain was trying to adapt to the experience of early trauma and maybe predict later threats, and which could translate into being hyper-responsive.”

The researchers injected a dye into the each rat’s brain so they could trace the neurons connecting the amygdala to the prefrontal cortex. Photo by Ruby Wallau/Northeastern University

The researchers injected a dye into the each rat’s brain so they could trace the neurons connecting the amygdala to the prefrontal cortex. Photo by Ruby Wallau/Northeastern University

To figure out the exact mechanism behind this change, the researchers needed to be able to examine brains more directly. In neuroscience research, that means they needed rats.

“What a young rat, just like a young human, needs the most for its well-being is proper caretaking and nurturing,” Brenhouse says. “If you disturb the infant-mother relationship somehow, that’s the way to best model early life adversity.”

The researchers removed male and female rat pups from their mothers for three to four hours every day during their infancy. The pups were separated into warm areas with bedding that smelled like their mother and littermates, but without any physical contact or caretaking.

“It mimics very much the situation for those institutionalized children, where they were in little individual cribs, left alone and not being taken care of for a long period of time,” Brenhouse says. “That induces a lot of the same stress response changes and behavior changes and brain changes that map on fairly well to what we see in humans.”

To see how the connections in the rats’ brains were developing, the researchers injected a dye into each animal’s basolateral amygdala. As those neurons extended from the amygdala to the prefrontal cortex, they would become stained with the dye, allowing researchers to identify them.

The researchers examined the rats’ brains at different points in development. They found marked differences between males and females. In female rats that were separated from their mother, an excess of new connections grew rapidly between the amygdala and the prefrontal cortex early on in development. Males saw some of this same nerve growth (known as innervation), but not until much later on.

The researchers also used an fMRI to examine the activity patterns of the animals’ brains when they were at rest. Animals with this excess innervation had abnormal communication between the amygdala and the prefrontal cortex.

“These excess neural connections were disturbing the efficiency of that circuit,” Brenhouse says. “Basically, the circuit didn’t work as well, and it didn’t mature as well.”

The animals whose brains developed abnormally also behaved differently. The researchers tested them for anxiety-like behaviors by placing the rats on an elevated plus-shaped platform. Two of the arms of the platform had walls, creating a more secure space, while the other arms were wide open. Rats with excess connections between the amygdala and the prefrontal cortex spent more time huddling in the areas with protective walls.

The early development of this circuit seemed to be creating a sense of hyper-vigilance in these animals.

“It’s the first time we’ve really seen a sex-specific circuitry change over development after early life stress,” Brenhouse says. “Early life trauma is actually setting up the circuit to develop differently.”

As for why females are more vulnerable to these changes, the researchers say they aren’t sure yet. Male and female brains mature differently, so this type of stress may be hitting females at a critical point in their development. Differences in hormones or immune systems could also play a role, or perhaps males and females simply experience stress in different ways.

“There’s a long list of theories that we want to follow up on,” Brenhouse says. “We know males are impacted by early life stress in other ways, but the circuit that we tested seems to be more impacted in females.”

The important thing, though, is that these changes don’t have to be permanent.

Understanding the differences in how male and female brains develop, and the impact of neglect on this process, could help improve treatments and interventions for children before mental illnesses begin to manifest themselves.

“I’m always worried when we talk about early life trauma that it sounds like once you experience it, then you’re broken,” Brenhouse says. “But the truth is, our brain continues to be plastic throughout our lives. Maladaptive circuitry can certainly be molded by later enrichment, interventions, and treatments.”

This story was originally published on News@Northeastern on February 20, 2020

July 09, 2020

What Squid Neurons and an Octopus on Ecstasy Can Teach Us about Ourselves

Cephalopods—the group of animals that includes octopus, squid, and cuttlefish—are well known for their incredible color-changing abilities. But these tentacled weirdos have also played a vital role in our evolving understanding of the human nervous system.
In honor of #CephalopodWeek, we spoke with Jade Zee, who directs Northeastern’s program in behavioral neuroscience, about what these animals can teach us.

“Among invertebrates, they stand very much apart. They’ve evolved a much larger nervous system,” says Zee. “Their body plan is completely different from ours, but they share many of the same fundamental principles in how the nervous system actually underlies behaviors.”

What have we discovered from studying cephalopods?

Neuroscience has really benefited from cephalopods. The very first action potential, which is the electrical activity of a neuron, was recorded in a squid.

Jade Zee. Photo by Matthew Modoono/Northeastern University

Jade Zee directs Northeastern’s program in behavioral neuroscience. Photo by Matthew Modoono/Northeastern University

We humans have white matter, which causes electrical signals to travel much, much faster in our neurons. Invertebrates don’t have that. So the invertebrate solution, if you want electrical signals travel faster, is to have a wider diameter axon of a neuron.
The very first action potentials were recorded in what’s called the squid giant axon. It’s about a millimeter in diameter, which I know still sounds small, but that’s actually really, really big compared to other nerves.
With the early techniques we had to record electrical activity, it was necessary to find some kind of system where the axon was physically bigger, so you could actually impale electrodes in it and record this electrical activity.
This recording of an action potential in the squid giant axon is pretty fundamental. It’s what I teach in my neurobiology course and in biological psychology.

Why is the axon so big?

If you think in terms of evolution, the behaviors that need to happen fast would generally be escape behaviors. Having this giant axon that was wider and thicker would allow electrical signals to travel faster in their bodies, and that would help them escape dangerous situations or predators.

How are cephalopods used in neuroscience today? Are researchers still studying that axon?

While it might have started out as just a great fundamental system to understand nervous system physiology, it has really branched out, in part because of their complex behaviors, and also because they have very interesting sensory capabilities.
Cephalopods do have a small brain, but their nervous system is not like a central nervous system. The neurons are clustered all over the place, kind of in a network. Those clusters are called ganglia. And from there, they have some independent control of a segment of the body. There are clusters of neurons located out in the arms that are responsible for a lot of the really interesting behaviors and motor control.
And for someone like me, who’s interested in the neural basis of behavior, there’s a lot of sort of quirky stories in the news about how complex their cognitive ability is. I don’t work on cephalopods, but I appreciate them as a neuroscientist.

A study came out last fall where researchers dosed octopuses with ecstasy (MDMA) to see how their behavior would change. What can we learn from studies like this?

The scientists who research this are actually conducting some experiments in the “Neural Systems and Behavior” course I co-direct at the Marine Biological Laboratory in Woods Hole.
We know, with humans, ecstasy promotes what we call pro-social behaviors. Their question was to ask whether or not the same sort of mechanism happens in cephalopods. And that turns out to be the case.
They used a species of octopus that is mostly solitary. When they were treated with ecstasy, they started being less interested in toys and more interested in each other. They were more gregarious. What it actually showed us was that they have a very similar system underlied by serotonin, which is exactly why humans also like MDMA.
MDMA is currently being tested in terms of its potential therapeutic benefits for treating PTSD. It’s useful to know that what’s happening from a neurochemical standpoint in humans is also happening in cephalopods.
This story was originally published on News@Northeastern on June 27, 2019.

July 09, 2020
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The Science of Movement

Northeastern professor Dagmar Sternad is studying ballet dancers to understand how to help people regain their balance in old age. Her findings could help us improve our mobility, design better robots, and discover how to more effectively treat stroke patients.

July 09, 2020
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The Program That's Training the Students who could Transform Cancer Treatment

Amanda Stroiney, who is developing a mobile app that delivers personalized treatment information to people with breast cancer, and who is applying to medical school with an eye toward oncology, never expected to work in the field of cancer research.
She studied behavioral neuroscience and criminal justice at Northeastern and planned to study brains.
But then she did a co-op at the Dana-Farber Cancer Institute through a Northeastern program that created opportunities for undergraduate students to gain hands-on training in cancer nanomedicine. The program allowed her to work with top cancer researchers at Dana-Farber, which is one of the leading cancer treatment and research centers in the world. And her experience changed everything.
Since its inception in 2015, 75 students have completed the same program Stroiney did—called Cancer Nanomedicine Co-ops for Undergraduate Research Experiences, or CaNCURE, for short.

“I really believe CaNCURE launched my career,” says Amanda Stroiney, who recently applied to medical school with an eye toward oncology. Photo by Matthew Modoono/Northeastern University


In early June, CaNCURE received a $1.5 million grant from the National Cancer Institute, a branch of the federal National Institutes of Health, to support the work of 80 more undergraduate students over the next five years.

“What we’re doing is putting together our great students with the world’s best researchers in nanomedicine, training them to become cancer researchers,” says Srinivas Sridhar, University Distinguished Professor of Physics at Northeastern, who directs the program.

And, it appears to be working. “Over two-thirds of our alumni have stated that what they learned in CaNCURE helped them land their first job or get into medical school,” says Anne van de Ven, who is a research assistant professor of physics and the associate director of the program.
Stroiney was among the first students to take advantage of the program, just before she graduated in 2016.
She worked in the radiology department at Dana-Farber, studying two different imaging techniques that are used to diagnose a patient’s cancer.

Toward the end of her final year at Northeastern, Stroiney got two job offers on the same day. The first offer was related to her major, doing neurological behavioral studies. It’s the job she probably would’ve seen herself in, as a freshman. The second offer was for a clinical research position within the Center for Immuno-Oncology at Dana-Farber, and more aligned with what she did in CaNCURE.
She chose Dana-Farber.

“I really believe CaNCURE launched my career,” Stroiney says, three years after that fork-in-the-road

Inspired by her experience in CaNCURE, Stroiney is also helping to create a mobile app for breast cancer patients, seen here. Photo by Matthew Modoono/Northeastern University

day. She was sitting in the bustling co-working space in Cambridge, Massachusetts, out of which she’s working to create a personalized cancer treatment app.

Hers is a sentiment echoed by other CaNCURE alumni, including Sarah Sherman.
Sherman, who graduated from Northeastern in 2017 with a combined degree in biology and English, says she applied to the CaNCURE program because she wanted to gain experience in research, knowing it was a common career path for people in science fields.
She worked at Massachusetts General Hospital in a molecular imaging lab, where she was put in charge of testing a new breast cancer treatment to determine if it would be effective enough for clinical trials. It wasn’t, but Sherman says the experience inspired her profoundly. After she graduated, Sherman won a prestigious Fulbright Scholarship to do cancer research in Botswana. Since then, she’s worked at a small biomedical company that’s seeking to transform how diseases are detected.

“CaNCURE was pretty pivotal for me, particularly because before the program, I hadn’t done research outside a classroom setting,” Sherman says. “Without that initial opportunity to gain skills, I wouldn’t have felt as confident to take advantage of other opportunities along the way that have led me here.”

Sherman and Stroiney are among several students, faculty, staff, and alumni in the nanomedical field whose work will be highlighted at the fifth annual Nanomedicine Day at Northeastern on Thursday, June 13 in the Raytheon Amphitheater. Registration is not required to attend. A full agenda for the day can be found online.
This story was originally published on News @ Northeastern on June 12th, 2019.

July 09, 2020

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