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Kim Lewis

Kim Lewis

University Distinguished Professor

Expertise:

  • Molecular Microbiology

About Kim Lewis

Our laboratory studies persister cells and uncultured bacteria. Persisters are dormant variants of regular cells which are tolerant to antibiotics and responsible for recalcitrance of biofilm infections. Using transcriptome analysis, cell sorting and whole genome sequencing we are identifying genes responsible for persister formation. We identified a number of mechanisms for persister formation, and the first compound that kills them, acyldepsipeptide. Uncultured bacteria make up the majority of species on the planet, but do not grow in the lab. We developed a general method to grow these organisms by cultivation in their natural environment. In marine sediment, siderophores from neighbors serve as growth factors for uncultured bacteria. We have recently identified growth factors for uncultured bacteria from the human microbiome. We also use uncultured bacteria as a source for discovering new antibiotics.

 

Give to the Lyme Disease Research Fund

Contact

Mailing Address:

134 MU (Mugar Life Sciences Building), Boston, MA 02115
Institutes, Labs & Research Centers
Antimicrobial Discovery Center
Biotechnology

The Center translates basic discoveries into novel antimicrobial therapies to combat Biowarfare and conventional pathogen threats. The rise of multidrug resistant pathogens and the threat of genetically engineered bioweapons represent an urgent need for antimicrobial therapies. The Center is funded by grants from the NIH, NSF, and DOE.

Faculty
Lewis Lab
Biology
Biochemistry

The Lewis Lab studies persister cells responsible for tolerance to antibiotics, uncultured bacteria of the environment and the microbiome, and works on drug discovery.

Faculty

Publications:

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