Research in Dr. Agar’s group characterizes post-translational modifications of proteins and changes in protein, peptide, and lipid expression that occur during ALS, and then determines which of these changes have structural or toxic consequences. They use a variety of techniques but are best known for contributions to top-down mass spectrometry development. Currently, the group is now developing a potential drug for ALS based upon these studies.
Publications
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News
Breakthrough ALS research: Free tool from Northeastern scientists could revolutionize drug development
Professor Jeffrey Agar, chemistry and chemical biology, is working with a team to revolutionize drug development, pointing to potential breakthroughs in ALS research. -
Breakthrough that can halt the progression of ALS developed by Northeastern scientist
A major breakthrough in the treatment of amyotrophic lateral sclerosis, known as ALS, can potentially help stop the disease in its tracks in as much as half of the cases in the U.S., a Northeastern University scientist says. Jeffrey Agar, associate professor of chemistry and pharmaceutical sciences at Northeastern, has spent the last 12 years […] -
Celebrating our COS 2023 TIER1 Awardees
11 are faculty members of the College of Science are 2023 TIER1 Awardees. The TIER 1 Seed Grant/Proof of Concept Program awards are supported by the colleges and the Senior Vice Provost for Research. -
The human genome has been mapped. Here’s the next monumental step.
Jeffrey Agar and his colleagues are working on helping humanity develop treatments for hundreds of currently untreatable diseases