A core motivation that drives this work is the search for specific network-level signatures or “fingerprints” that co-vary with heritable behavioral variation in the general population and mark vulnerability for psychiatric illness onset. To date, research on the biological origins of psychopathology has largely focused on discrete illness categories. Although patient groups within this diagnostic system are treated as distinct entities, there are often murky boundaries between health and disease and across the disorders themselves. To establish the etiology of these complex syndromes, we must account for diagnostic heterogeneity, both relatively selective and disorder-spanning symptoms, and the dimensional nature of genetic risk.