Proteomimetic Polymers for Expanding the Druggable Proteome

In this presentation, we will describe the development of a new class of peptide polymer conjugate accessed via graft-through polymerization of peptidyl-monomers. The resulting dense array of peptides gives rise to key emergent properties that we exploit for the development of these materials as therapeutics: 1) Multivalency, 2) High molecular weight and tunable length scales, 3) Proteolytic/chemical stability and 4) Efficient intracellular penetration. We will highlight examples of the utility of this approach for engaging critical intracellular protein-protein interactions driving neurodegenerative disease and cancer.