Faculty Labs and Research

Professor Ondrechen’s research group spans the areas of theoretical and computational chemistry, computational biology, bioinformatics, protein design, and drug discovery. Areas of interest include functional genomics – predicting the biochemical functional roles of gene products (proteins), protein engineering, providing computational guidance for drug discovery, and understanding the fundamental basis for enzyme catalysis.

The Slavov Lab studies Ribosome-mediated translational regulation, and single-cell proteomics by mass-spectrometry

The Lee-Parsons Laboratory applies metabolic engineering principles and methodologies to improve the production of important compounds (i.e., critical plant-derived pharmaceuticals or biofuels from plant cell and tissue cultures and microalgae cultures.

The O’Doherty Group research interests broadly encompass the discipline of organic synthesis toward designing, synthesizing and testing new anticancer, antibacterial and antiviral agents. 

The research program in the Laboratory for Neglected Disease Drug Discovery focuses on those areas of research that will impact on treatment of human disease and on areas that will expedite the drug discovery process.

The Beuning Laboratory at Northeastern is focused on understanding the structure-function-dynamics relationships of proteins and enzymes, with a particular focus on proteins involved in DNA metabolism and DNA damage tolerance.

The Biomaterials Design Group works at the interface of bio-analytical chemistry, materials science, and design. We investigate fundamental mechanisms behind systems in biology and use our understanding to better inform the design new classes of protein-based biomaterials that may interface with or enhance the performance of humans.

The Engen Lab uses hydrogen exchange and mass spectrometry (HX MS) as our core technology to probe protein conformation, conformational changes, dynamics, protein folding and the effects of binding.

The Zhang Group develops macromolecular systems to provide answers to important questions in biology and medicine.

SunnyLand applies protein chemistry, analysis and engineering to biology and medicine.

The Lopez Research Group uses quantum mechanical and machine learning techniques to identify next-generation organic materials for applications in renewable energy and photomedicine.

The Manetsch Lab addresses various aspects of medicinal chemistry related to optimization of anti-malarial, anti-leishmanial, and anti-bacterial agents, as well as developing and applying LC/MS-based approaches facilitating synthetic and medicinal chemistry.