Dr. Fleury A Nsole Biteghe is a lecturer under the MS in Biotechnology program at Northeastern University. He holds a PhD with specialization in Medical Biotechnology and Immunotherapy, from the University of Cape Town (UCT). As a postdoctoral scientist at Cedars Sinai hospital, he has contributed to elucidating immune resistant mechanisms causing immunotherapeutic treatment failures. He has over 12 years of academic and industrial research expertise focused on the development of antibody drug conjugates (ADCs) and photoconjugates (APCs) for photoimmunotherapeutic (PIT) application. Dr. Biteghe scientific efforts are focused on PIT, a novel light-dependent therapy utilizing the targeted binding of antibody-IR700 conjugate to a specific tumor antigen, with subsequent illumination, causing ROS production thereby inducing rapid cell death. After acquiring industry experience at Rakuten Medical and Takeda Oncology, Dr Biteghe joined Global Health Catalyst (GHC), an organization whose mission is to curb the growing cancer crisis and save millions of lives by catalyzing win-win collaborations for global health and innovation. Additionally, he is interested in developing the next generation of biotech entrepreneurs and improving biotech accessibility to underprivileged and historically disadvantaged communities, through his Nucleate activities. He has extensive experience in teaching biotechnology and enjoys translating his industry and research experience for academic application.
Publications
- Advances in Etiopathological Role and Control of HPV in Cervical Cancer Oncogenesis
- CSPG4 as a target for the specific killing of triple-negative breast cancer cells by a recombinant SNAP-tag-based antibody-auristatin F drug conjugate
- Click Chemistry-Generated Auristatin F−Linker−Benzylguanine for a SNAP-Tag-Based Recombinant Antibody−Drug Conjugate Demonstrating Selective Cytotoxicity toward EGFR-Overexpressing Tumor Cells
- CD8+ T-cells Immune Escape by SARS-CoV-2 Variants of Concern
- Synergistic effects of radiotherapy and targeted immunotherapy in improving tumor treatment efficacy: a review
- Detection of Circulating VZV-Glycoprotein E-Specific Antibodies by Chemiluminescent Immunoassay (CLIA) for Varicella–Zoster Diagnosis
- Treatment of Chikungunya Virus (CHIKV) Using Targeted Immunotherapy
- Advances in epidermal growth factor receptor specific immunotherapy: lessons to be learned from armed antibodies
- Desensitization of metastatic melanoma cells to therapeutic treatment through repeated exposure to dacarbazine
- Antibody-Based Immunotherapy : Alternative Approaches for the Treatment of Metastatic Melanoma
- Effect of aqueous extracts of Ficus vogeliana Miq and Tieghemella africana Pierre in 7,12-Dimethylbenz(a)anthracene -induced skin cancer in rats
- Antibody-Based Targeted Interventions for the Diagnosis and Treatment of Skin Cancers
- Applications of SNAP ‐ tag technology in skin cancer therapy
- Human Antibody Fusion Proteins/Antibody Drug Conjugates in Breast and Ovarian Cancer
- A combination of photodynamic therapy and chemotherapy displays a differential cytotoxic effect on human metastatic melanoma cells
- Draft Genome Sequences of Three Bacillus Species from South African Marine Sponges
- Enhancing Photodynamic Therapy in Skin Cancer: Important considerations to increase PDT efficacy
In The News
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Research
Northeastern researcher uses light to target and kill cancer cells
Fleury Augustin Nsole Biteghe has identified a way to target two of the deadliest cancer types with chemotherapy drugs but without the harms associated with chemotherapy. -
Student Spotlight
Undergraduate Student Experience Spotlight: Hope Zamora
I am Hope Zamora a major in behavioral neuroscience on the pre-med track. I am also in the Honors Program. I will be graduating in May of 2023. -
A Guide to Mindful Meditation
Aaron Daniels, psychology professor and mindfulness fellow at Northeastern, explains how meditation can lead to living life more intentionally, and how it’s benefited him on his own personal journey. -
The best way to get back to normal after devastating tornadoes? Just start somewhere.
As residents in America’s heartland grapple with grief and devastation following Friday’s tornado outbreak, shaken survivors may find small steps to recovery come from a return to simple routine, such as a visit to the dog park or a chance to bring the kids ice skating, says Daniel Aldrich, a Northeastern professor who studies post-disaster...