Lori Ferrins

Sponsor: NIH AViDD Center Development Grant

Development of covalent SARS-CoV-2 papain-like protease inhibitors

There are two goals in this project, firstly, to continue to develop our advanced hit compound (disclosed here: doi: 10.1038/s41467-023-37254-w) to identify a lead suitable for in vivo proof of concept studies. Secondly, to develop novel methods to study the structural dynamics of both covalent inhibitors and PLpro active site structures enabling the development of more potent covalent inhibitors.