The axolotl salamander regenerates its limbs and tail by mounting a massive proliferative response in cells adjacent to the injury. To study this proliferative response, we created a line of axolotls where cells fluoresce different colors depending on where the cell is in the cell cycle; cells that are diving or preparing to divide fluoresce green while cells that are resting fluoresce red. We then used this system to visualize the proliferative response that occurs following limb and tail amputation.
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