Javier Apfeld

Sponsor: National Institute of Aging

Genome-Wide CRISPR Activation: A Novel Strategy for Identifying Anti-Aging Targets

This project will characterize and optimize a novel time and cost saving toolkit that allows simple, rapid, and robust activation of gene expression in the widely used model organism C. elegans, bringing new capabilities to systematically test the effect of gene activation in a broad range of biological problems. These capabilities will be employed to search for novel genes whose activation promotes healthy aging and increases lifespan.