Eddie Geisinger
Sponsor: Broad Inst
Attacking failure of antibiotic treatment by targeting antimicrobial resistance enabler cell-states |
| This project aims to uncover the genetic mechanisms that underlie antibiotic treatment failure in hospital-acquired bacterial infections. We will analyze “enabler” mutations and phenotypes that promote antibiotic tolerance and act as stepping stones for the development of antibiotic resistance and treatment failure. A major focus is the pathogen Acinetobacter baumannii, which causes hospital-acquired diseases including pneumonia and sepsis that have become increasingly difficult to treat. |