Alexander Ivanov

Sponsor: NIH, NIGMS

Next-generation nanoflow LC column technology to enable high sensitivity proteomics of limited samples. 

Deep proteomic profiling of scarce biological and clinical samples is still a major challenge since no amplification techniques are available for proteins and proteoforms, and current state-of-the-art proteomic techniques based on conventional chromatography columns coupled with mass spectrometry provide suboptimal performance and sensitivity levels. In this study, based on our novel, currently unavailable on the market, chromatographic column technology, we plan to build a reliable, robust, thoroughly evaluated commercialization-ready prototype chromatography platform to enable ultrasensitive proteomic profiling and address the challenges of numerous clinical, academic, and industrial laboratories. If successful, we will commercialize the technology to satisfy current customer needs in high-sensitivity proteomic analysis and tackle numerous biological and pathological phenomena that currently could not be investigated in amount-limited samples.