Aaron Seitz (NU Site PI)

To utilize resting state functional MRI to evaluate cognitive outcomes in pediatric brain tumor patients and also to inform optimization of radiation therapy treatment plans to decrease cognitive side effects. Additionally, our goal is to establish the role of sleep quality and cognitive performance and resting state network organization in pediatric brain tumor patients.

Specific Aim(s):

Aim 1: Determine the long-term trajectory of cognitive outcome and individual-specific functional brain network organization in PBT survivors.

Aim 2: Determine the interaction of sleep quality and fluctuations in executive function in PBT survivors.

Aim 3: Prospective Evaluation of Radiation-Induced Alterations in Brain Resting State Networks and their Impact on Cognitive Outcome.