New developments in non-linear Raman microscopy – Physics Colloquia

Dr. Shi is developing and applying new ultrafast laser scanning optical imaging and spectroscopic technologies- this includes stimulated Raman scattering (SRS) spectroscopy, and multiphoton microscopy (MPM). These imaging techniques are used to investigate cellular metabolism, neurodegenerative diseases, cancer, drug delivery, and development in living organisms. She is combining bioorthogonal labeling SRS and MPM for directly visualizing in situ complex molecular events in brain, tumor, and metabolic diseases at sub-cellular scale. These approaches represent powerful tools for disease detection, diagnosis and treatment, as well as for mechanistic understanding of scientific fundamentals.

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