Faculty Labs and Research

The Geisinger Lab investigates the molecular basis of antibiotic resistance and disease development in infections with hospital-acquired pathogens.

The Day Lab investigates the molecular role of G quadruplex DNA in genome stability and human disease.  

Khrapko’s Lab is studying mutations in mtDNA and their effects on cellular physiology, aging and disease. They also use mtDNA mutations to trace mtDNA lineages and to study human evolution.

Dr. Tilly’s lab seeks to promote a deeper understanding of the genetic and epigenetic drivers of cell lineage specification, differentiation and death, and to then utilize the information gained from these studies for development of innovative new technologies to improve human health within and across generations.

The Institute develops imaging tools to highlight chemical processes – enabling clinicians to better diagnose and treat disease.

The Center translates basic discoveries into novel antimicrobial therapies to help resolve the Antimicrobial Resistance Crisis, a slow-moving pandemic, according to the WHO. combat Biowarfare and conventional pathogen threats. The Center is funded by grants from the NIH, The Schmidt Futures and the Steven & Alexandra Cohen Foundation.

This institute focuses on the role of tissue inflammation in fighting disease and infection, and the mechanisms that control tissue inflammation in the body. The Institute’s work has immediate implications for anti-cancer strategies and approaches to improved vaccines.

The Ionescu Lab studies skeletal development, pathology, and regeneration, focusing on stem cell fate mapping, lineage tracing, and single-cell transcriptomics to uncover mechanisms of skeletal growth and repair.

The Interdisciplinary Affective Science Laboratory (IASL) studies emotions what they are, and how they work— using experiential, behavioral, psychophysiological, and brain-imaging techniques. The IASL is located at Northeastern University, with a secondary site at Mass General Hospital.

The Saavedra Lab investigates host-microbe interactions in health and disease through an immunology and cell biology lens.

The Copos Lab is broadly interested in mathematical biology of the cell. They are a group of interdisciplinary scientists that develop models and new mathematical tools to tease apart the “internal machinery” of a living cell. Their work combines mechanics-based mathematical modeling, numerical and computational methods, image-based analysis and inference, and collaborations with experimentalists.

Okeke Lab investigates the molecular mechanisms associated with the inflammatory response of innate immune cells with a focus on neutrophils and macrophages. Specifically, we are interested in pathways associated with the release of neutrophil extracellular traps (NETs) and the contribution of NETs to different diseased states including diseases of the central nervous system.