Owen Skinner

Sponsor: National Institutes of Health

Integrated mass spectrometry strategies to decipher metabolite-protein cross regulation

Metabolism depends on interactions between proteins and small-molecule metabolites, and when that regulation breaks down the result can be diseases ranging from epilepsy to cardiovascular disease — yet those interactions remain poorly understood, largely because few methods can probe both sides at once. The Skinner Lab is developing mass spectrometry–based strategies that integrate metabolomics with intact and native proteomics, applied to thiol regulation of core metabolic pathways and to the metabolic and redox roles of vitamin B6