What was supposed to be a weeklong test flight in space has turned into a months-long stay for astronauts Butch Wilmore and Suni Williams. While the unexpected delays from their mission may not have any negative side effects on the future of space exploration, it could affect their physical and mental health.

What happens to your body when you’re in outer space?

Jacqueline McCleary, assistant physics professor at Northeastern University, says the term for the effects of being in space are summed up by the acronym RIDGE, which stands for radiation, isolation and confinement, distance from Earth, gravity fields, and hostile/closed environments.

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AP Photo/Chris O’Meara, File