Penny Beuning

Associate Professor
Location: 102 HT (Hurtig Hall), Boston, MA 02115

Area(s) of Expertise

  • Chemical Biology and Biotechnology

Publications

About

The research in the Beuning laboratory encompasses the following areas: We aim to determine how cells respond to DNA damage and maintain the accuracy of genetic information, by studying the specificity of DNA-damage bypass Y-family DNA polymerases for different types of damage, by probing interactions between DNA replication and DNA…

The research in the Beuning laboratory encompasses the following areas:

We aim to determine how cells respond to DNA damage and maintain the accuracy of genetic information, by studying the specificity of DNA-damage bypass Y-family DNA polymerases for different types of damage, by probing interactions between DNA replication and DNA damage tolerance, and by determining the genes responsible for tolerance to specific DNA damaging agents. As part of this work, we aim to develop DNA damage tolerance enzymes and DNA repair proteins as tools for biotechnology applications. 

We also seek to determine fundamental aspects of enzyme function that can be applied to protein engineering. This work, largely in collaboration with the Ondrechen laboratory, probes the roles of residues remote from the active site in enzyme function. This work focuses on a wide range of enzymes, from DNA polymerases to enzymes involved in the urea cycle and sugar metabolism. A second goal of this project is to determine the functions of enzymes of unknown function from structural genomics projects.

Associate Professor Beuning in the news

Future Faculty Workshop success for women in STEM

During a full day in the Egan Research Center, the 80 participants of the New England Future Faculty Workshop for women in STEM fields gained vital insight, advice, and pro-tips from faculty panels, one-on-one CV reviewers, and interdisciplinary groups of faculty members.
Penny Beuning

Chemistry professor earns Young Investigator Award from ACS

by Emily Ashbolt, Biomedical Physics, 2017 For the past decade, Northeastern University Chemistry and Chemical Biology professor Penny Beuning has focused her research on cellular responses to DNA damage, specifically a family of DNA polymerases that deal with copying the damaged DNA. Her tireless work in this area of chemistry has earned her the Chemical Research […]

Probing Relationships between Protein Structure and Movement

Penny Beuning’s research is based on relationships. Proteins, DNA, RNA in a dance of scientific compatibility. A dance that affects life, the fight against disease and understanding how to create new chemical reactions. An associate professor in Chemistry and Chemical Biology at Northeastern’s College of Science, Beuning’s groundbreaking efforts were documented recently in a paper published in “Structure.” In it, she detailed how various proteins might act in different situations…