Denise Jackson

Associate Professor
Location: 125 NI (Nightingale Hall), Boston, MA 02115

Area(s) of Expertise

  • and behavioral consequences of prenatal cocaine exposure on monoaminergic brain circuits, Extrapyramidal Movement Disorders: Neurochemical alterations in Parkinson’s disease; the role of dopamine in the therapeutic efficacy of l-dihydroxyphenylalanine, neurochemical, Psychomotor Stimulant Exposure: Neuroanatomical

About

Dr. Jackson’s research focuses on the effects of prenatal exposure to psychomotor stimulants (i.e., amphetamine, cocaine, etc.) on brain monoaminergic systems in developing rodent offspring. Her research group examines the impact of drug-induced alterations of these monoaminergic systems on post-synaptic function. These studies are particularly relevant to the issues of…

Dr. Jackson’s research focuses on the effects of prenatal exposure to psychomotor stimulants (i.e., amphetamine, cocaine, etc.) on brain monoaminergic systems in developing rodent offspring. Her research group examines the impact of drug-induced alterations of these monoaminergic systems on post-synaptic function. These studies are particularly relevant to the issues of permanent neurological deficits in children exposed to stimulant drugs in utero, and to the development of more effective and specific drug therapies. A major goal of this research is to characterize short- and long-term effects of prenatal drug exposure in rat offspring. Of particular interest is elucidating these effects at the neuroanatomical and biochemical levels. The neuroanatomical studies involve the use of immunocytochemical staining techniques to visualize cells in the brain and a computer-assisted image analysis system for quantification of drug effects. Neurochemical investigations are aimed at elucidating the functional consequences of drug-induced anatomical alterations. Ongoing studies utilize an in vitro slice preparation and in vivo brain microdialysis to measure basal and evoked neurotransmitter release.

Associate Professor Jackson in the news

College of Science hosts first diversity town hall for graduate students

This October, the first Diversity Town Hall for Graduate Students was held in collaboration with College of Science Dean Ken Henderson, Professor Carla Mattos of the Department of Chemistry, Professor Denise Jackson of the Department of Psychology, members from the Office of Institutional Diversity and Inclusion (OIDI), and collection of graduate students representing many departments in the college.